Modelling Immunological Memory

Garrett, Simon and Robbins, Martin and Walker, Joanne and Wilson, William and Aickelin, Uwe (2006) Modelling Immunological Memory. In: Silico Immunology. Springer, pp. 83-108.

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Abstract

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves.

Item Type: Book Section
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Computer Science
Depositing User: Aickelin, Professor Uwe
Date Deposited: 12 Oct 2007 15:08
Last Modified: 12 Oct 2007 15:08
URI: http://eprints.nottingham.ac.uk/id/eprint/585

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