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Zheng, Zai-Qin, Wei, Wen-Jun, Zhang, Junmin, Li, Hang-Ying, Xu, Kai, Xu, Jiayuan, Tang, Bencan, Li, Ya and Gao, Kun (2019) Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica. Journal of Organic Chemistry, 84 (7). pp. 4473-4477. ISSN 0022-3263

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Abstract

Heliaquanoid A (1), the first exo-2,4-linked Diels−Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B−E (2−5), four new 2,4-linked Diels−Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by the NMR spectroscopy, modified Mosher′s method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively.

Item Type:	Article
Additional Information:	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Organic Chemistry,copyright ©American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.joc.8b03284
Schools/Departments:	University of Nottingham Ningbo China > Faculty of Science and Engineering > Department of Chemical and Environmental Engineering
Identification Number:	https://doi.org/10.1021/acs.joc.8b03284
Depositing User:	Zhou, Elsie
Date Deposited:	09 May 2019 10:21
Last Modified:	18 Mar 2020 04:30
URI:	https://eprints.nottingham.ac.uk/id/eprint/56622

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