Attenuated post-movement beta rebound associated with schizotypal features in healthy people

Benjamin A.E., Hunt and Elizabeth B., Liddle and Lauren E., Gascoyne and Lorenzo, Magazzini and Bethany C., Routley and Krish D., Singh and Peter G., Morris and Matthew J., Brookes and Peter F., Liddle (2018) Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin . ISSN 1745-1701

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Abstract

Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in Schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound (PMBR)), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR.

Methods: 116 participants completed a visuomotor task whilst their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring Cognitive-Perceptual, Interpersonal and Disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for.

Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between Interpersonal and Disorganization factor scores.

Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.

Item Type: Article
Keywords: Magnetoencephalography; Schizotypy; Schizophrenia; Individual Differences; Schizotypal Personality Disorder; Psychosis
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: https://doi.org/10.1093/schbul/sby117
Depositing User: Lashkova, Mrs Olga
Date Deposited: 07 Sep 2018 08:58
Last Modified: 21 Sep 2018 09:27
URI: http://eprints.nottingham.ac.uk/id/eprint/53812

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