Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations

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Gomm, Andrew, Grigoriou, Stylianos, Peel, Christopher, Ryan, James, Mujtaba, Nafees, Clarke, Thomas, Kulcinskaja, Evelina and O'Reilly, Elaine (2018) Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry . ISSN 1099-0690

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201800799

Abstract

The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries.

Item Type:	Article
Schools/Departments:	University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number:	https://doi.org/10.1002/ejoc.201800799
Depositing User:	Eprints, Support
Date Deposited:	06 Sep 2018 10:00
Last Modified:	06 Jul 2019 04:30
URI:	https://eprints.nottingham.ac.uk/id/eprint/53766

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