Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations

Gomm, Andrew and Grigoriou, Stylianos and Peel, Christopher and Ryan, James and Mujtaba, Nafees and Clarke, Thomas and Kulcinskaja, Evelina and O'Reilly, Elaine (2018) Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry . ISSN 1099-0690

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Abstract

The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/ejoc.201800799
Depositing User: Eprints, Support
Date Deposited: 06 Sep 2018 10:00
Last Modified: 06 Jul 2019 04:30
URI: http://eprints.nottingham.ac.uk/id/eprint/53766

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