Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules

Clark, Marcia E. and Bedford, Laura E. and Young, Ben and Robertson, John F.R. and das Nair, Roshan and Vedhara, Kavita and Littleford, Roberta and Sullivan, Francis M. and Mair, Frances S. and Schembri, Stuart and Rauchhaus, Petra and Kendrick, Denise (2018) Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124 . pp. 160-167. ISSN 0169-5002

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Abstract

Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population.

Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n=338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met.

Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means -1.99, 95%CI -4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI -1.32, 3.08; p-value for change over time =0.003) with similar findings using loge transformed data.

Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan.

Item Type: Article
Keywords: Pulmonary nodules; Lung cancer screening; Psychological impact
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Psychiatry and Applied Psychology
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Primary Care
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.1016/j.lungcan.2018.08.001
Depositing User: Eprints, Support
Date Deposited: 31 Aug 2018 08:29
Last Modified: 03 Aug 2019 04:30
URI: http://eprints.nottingham.ac.uk/id/eprint/53572

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