Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway

Monaghan, Tanya M. and Mullish, Benjamin H. and Patterson, Jordan and Wong, Gane K.S. and Marchesi, Julian R. and Xu, Huiping and Tahseen, Jilani and Kao, Dina (2018) Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes . ISSN 1949-0976

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Abstract

The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/947614
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Gut microbes on 05/09/2018, available online: http://www.tandfonline.com/1080/19490976.2018.1506667
Keywords: microbiota; fecal microbiota transplantation (FMT); recurrent Clostridium difficile infection (rCDI); bile acid metabolism; fibroblast growth factor (FGF)19
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
University of Nottingham, UK > Faculty of Science > School of Computer Science
Identification Number: doi:1080/19490976.2018.1506667
Depositing User: Jones, Natalie
Date Deposited: 23 Jul 2018 10:29
Last Modified: 04 May 2020 19:47
URI: http://eprints.nottingham.ac.uk/id/eprint/53079

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