An ensemble code in medial prefrontal cortex links prior events to outcomes during learning

Maggi, Silvia and Peyrache, Adrien and Humphries, Mark D. (2018) An ensemble code in medial prefrontal cortex links prior events to outcomes during learning. Nature Communications, 9 (1). 2204/1-2204/12. ISSN 2041-1723

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Abstract

The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cortex’s role in short-term memory. Here we ask if the encoding of short-term memory in prefrontal cortex is used by rats learning decision rules in a Y-maze task. We find that a similar pattern of neural ensemble activity is selectively recalled after reinforcement for a correct decision. This reinforcement-selective recall only reliably occurs immediately before the abrupt behavioural transitions indicating successful learning of the current rule, and fades quickly thereafter. We could simultaneously decode multiple, retrospective task events from the ensemble activity, suggesting the recalled ensemble activity has multiplexed encoding of prior events. Our results suggest that successful trial-and-error learning is dependent on reinforcement tagging the relevant features of the environment to maintain in prefrontal cortex short-term memory.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/936646
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.1038/s41467-018-04638-2
Depositing User: Eprints, Support
Date Deposited: 20 Jul 2018 11:53
Last Modified: 04 May 2020 19:39
URI: http://eprints.nottingham.ac.uk/id/eprint/53063

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