Endocrine therapy for breast cancer: a model of hormonal manipulation

Johnston, Simon J. and Cheung, Kwok-Leung (2018) Endocrine therapy for breast cancer: a model of hormonal manipulation. Oncology and Therapy . ISSN 2366-1089

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Abstract

Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/946037
Keywords: Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine
Identification Number: https://doi.org/10.1007/s40487-018-0062-x
Depositing User: Eprints, Support
Date Deposited: 17 Jul 2018 09:08
Last Modified: 04 May 2020 19:45
URI: http://eprints.nottingham.ac.uk/id/eprint/52982

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