Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles

Rodrigues, Mafalda and Russo, Lorenzo and Aguilo, E. and Rodriguez, L. and Ott, I. and Pérez-García, Lluïsa (2015) Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles. RSC Advances, 6 . pp. 2202-2209. ISSN 2046-2069

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Abstract

A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicating that compounds 2–4 are promising cytotoxic agents. Furthermore, the ability of these compounds to be associated with gold nanoparticles was also explored, in order to develop an anticancer drug delivery system. The free ligands displayed more activity when compared with the ligands immobilized on the gold nanoparticles. The synthesized gold particles incorporating the bis-imidazolium salts either 2 or 3 showed monodisperse spherical shape with sizes of approximately 5 nm.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/768843
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1039/C5RA21621D
Depositing User: Perez Garcia, Lluisa
Date Deposited: 13 Jul 2018 08:54
Last Modified: 04 May 2020 17:26
URI: http://eprints.nottingham.ac.uk/id/eprint/52915

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