A fellowship of Ring1 maintains AML stem cells

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Heery, David M. (2018) A fellowship of Ring1 maintains AML stem cells. Blood, 131 (16). pp. 1771-1773. ISSN 1528-0020

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Abstract

Polycomb repressive complex 1 (PRC1) and PRC2 are transcriptional repressors that function as key regulators of the self-renewal and differentiation (cell lineage specification) pathways in stem cells. In this issue of Blood, Shima et al1 report that 2 ubiquitin ligases (Ring1A and Ring1B), which are key components of PRC1 complexes, are essential for the establishment and maintenance of acute myeloid leukemia (AML) in mouse models.

Item Type: Article
Additional Information: This research was originally published in Blood. Heery, David M.. A fellowship of Ring1 maintains AML stem cells. Blood. 2018;Vol 131:pp. 1771-1773. © 2018 the American Society of Hematology.
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1182/blood-2018-02-832121
Depositing User: Eprints, Support
Date Deposited: 12 Jul 2018 08:04
Last Modified: 19 Apr 2019 04:30
URI: https://eprints.nottingham.ac.uk/id/eprint/52899

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