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van Baarsen, K.M., Kleinnijenhuis, M., Jbabdi, S., Sotiropoulos, S.N., Grotenhuis, J.A. and van Cappellen van Walsum, A.M. (2016) A probabilistic atlas of the cerebellar white matter. NeuroImage, 124,Pt (A). pp. 724-732. ISSN 1053-8119

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Abstract

Imaging of the cerebellar cortex, deep cerebellar nuclei and their connectivity are gaining attraction, due to the important role the cerebellum plays in cognition and motor control. Atlases of the cerebellar cortex and nuclei are used to locate regions of interest in clinical and neuroscience studies. However, the white matter that connects these relay stations is of at least similar functional importance. Damage to these cerebellar white matter tracts may lead to serious language, cognitive and emotional disturbances, although the pathophysiological mechanism behind it is still debated. Differences in white matter integrity between patients and controls might shed light on structure–function correlations. A probabilistic parcellation atlas of the cerebellar white matter would help these studies by facilitating automatic segmentation of the cerebellar peduncles, the localization of lesions and the comparison of white matter integrity between patients and controls.

In this work a digital three-dimensional probabilistic atlas of the cerebellar white matter is presented, based on high quality 3 T, 1.25 mm resolution diffusion MRI data from 90 subjects participating in the Human Connectome Project.

The white matter tracts were estimated using probabilistic tractography. Results over 90 subjects were symmetrical and trajectories of superior, middle and inferior cerebellar peduncles resembled the anatomy as known from anatomical studies.

This atlas will contribute to a better understanding of cerebellar white matter architecture. It may eventually aid in defining structure–function correlations in patients with cerebellar disorders

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/768242
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number:	https://doi.org/10.1016/j.neuroimage.2015.09.014
Depositing User:	Eprints, Support
Date Deposited:	11 Jul 2018 09:50
Last Modified:	04 May 2020 17:25
URI:	https://eprints.nottingham.ac.uk/id/eprint/52873

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