Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry

Khaled, Shaban A. and Alexander, Morgan R. and Irvine, Derek J. and Wildman, Ricky D. and Wallace, Martin J. and Sharpe, Sonja and Yoo, Jae and Roberts, Clive J. (2018) Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech . ISSN 1530-9932 (In Press)

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Abstract

An extrusion based 3D printer was used to fabricate paracetamol tablets with different geometries (mesh, ring, and solid) from a single paste-based formulation formed from standard pharmaceutical ingredients. The tablets demonstrate that tunable drug release profiles can be achieved from this single formulation even with high drug loading (>80% w/w). The tablets were evaluated for drug release using a USP dissolution testing type I apparatus. The tablets showed well-defined release profiles (from immediate to sustained release) controlled by their different geometries. The dissolution results showed dependency of drug release on the surface area/volume (SA/V) ratio and the SA of the different tablets. The tablets with larger SA/V ratios and SA had faster drug release. The 3D printed tablets were also evaluated for physical and mechanical properties including tablet dimension, drug content, weight variation, breaking force and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia. X-Ray Powder Diffraction, Differential Scanning Calorimetry, and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy were used to identify the physical form of the active and to assess possible drug-excipient interactions. These data again showed that the tablets meet USP requirement. These results clearly demonstrate the potential of 3D printing to create unique pharmaceutical manufacturing, and potentially clinical, opportunities. The ability to use a single unmodified formulation to achieve defined release profiles could allow, for example, relatively straightforward personalization of medicines for individuals with different metabolism rates for certain drugs and hence could offer significant development and clinical opportunities.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/938069
Schools/Departments: University of Nottingham, UK > Faculty of Engineering
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Depositing User: Eprints, Support
Date Deposited: 09 Jul 2018 08:32
Last Modified: 04 May 2020 19:40
URI: http://eprints.nottingham.ac.uk/id/eprint/52813

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