Relationships between neuronal oscillatory amplitude and dynamic functional connectivity

Tewarie, Prejaas K. and Hunt, Benjamin A. E. and O'Neill, George C. and Byrne, Aine and Aquino, Kevin and Bauer, Markus and Mullinger, Karen J. and Coombes, Stephen and Brookes, Matthew J. (2018) Relationships between neuronal oscillatory amplitude and dynamic functional connectivity. Cerebral Cortex, 29 (6). pp. 2668-2681. ISSN 1460-2199

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Abstract

Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in particular, whether such fluctuations reflect local dynamics, integration between regions, or both, is unknown. Here, using magnetoencephalography (MEG), we show that movement induced oscillatory modulation is associated with transient connectivity between sensorimotor regions. Further, in resting state data, we demonstrate a significant association between oscillatory modulation and dynamic connectivity. A confound with such empirical measurements is that increased amplitude necessarily means increased signal to noise ratio (SNR): this means that the question of whether amplitude and connectivity are genuinely coupled, or whether increased connectivity is observed purely due to increased SNR is unanswered. Here we counter this problem by analogy with computational models which show that, in the presence of global network coupling and local multistability, the link between oscillatory modulation and long range connectivity is a natural consequence of neural networks. Our results provide evidence for the notion that connectivity is mediated by neural oscillations, and suggest that time-frequency spectrograms are not merely a description of local synchrony but also reflect fluctuations in long range connectivity.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at: https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy136/5036075
Keywords: Dynamic functional connectivity; Amplitude envelopes; Magnetoencephalography; Coupled neural masses; Neural mass bifurcation; Neuronal oscillations; Time-frequency
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.1093/cercor/bhy136
Depositing User: Eprints, Support
Date Deposited: 08 Jun 2018 09:47
Last Modified: 12 Jun 2019 04:30
URI: http://eprints.nottingham.ac.uk/id/eprint/52313

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