Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

Lovato, Tatiana and Taresco, Vincenzo and Alazzo, Ali and Sansone, Catarina and Stolnik, Snjezana and Alexander, Cameron and Conte, Claudia (2018) Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B . ISSN 2050-7518 (In Press)

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Abstract

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/935413
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Depositing User: Eprints, Support
Date Deposited: 05 Jun 2018 08:08
Last Modified: 04 May 2020 19:38
URI: http://eprints.nottingham.ac.uk/id/eprint/52240

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