Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study

Abhishek, Abhishek and Courtney, Philip and Jenkins, Wendy and Sandoval-Plata, Gabriela and Jones, Adrian and Zhang, Weiya and Doherty, Michael (2018) Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis & Rheumatology . ISSN 2326-5205

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Abstract

Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout.

Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to their son(s) ≥20 years old. Sons interested in participating returned a reply-slip and underwent telephone screening. Subsequently they attended a study-visit for blood and urine collection, and musculoskeletal ultrasonography performed blind to serum urate (SU). Images were assessed for double contour sign (DCS), intra-articular or intra-tendinous aggregates/tophi, effusion and power Doppler. Logistic regression was used to examine associations.

Results 131 sons (mean age 43.80 years, body mass index 27.10 kg/m2) completed assessments. 64.1% had SU ≥6 mg/dl, and 29.8% had either DCS or intra-articular aggregates/tophi in ≥1 joint. All participants with MSU deposition had involvement of either 1st metatarsophalangeal joint. 21.4% had intra-tendinous aggregates, and these associated with intra-articular MSU crystal deposits (aOR (95%CI) 2.96(1.17-7.49)). No participant had MSU crystal deposition at SU ≤5 mg/dl, and 24.2% participants with SU between 5-6 mg/dl had ultrasonographic MSU deposition. MSU crystal deposition associated with increasing SU (aOR (95%CI) 1.61(1.10-2.36) for each 1 mg/dl increase).

Conclusion Asymptomatic sons of people with gout frequently have hyperuricemia and MSU crystal deposits. In this study MSU crystal deposits were present in participants with SU >5 mg/dl. Evaluation of people without a family history of gout is needed to confirm if the threshold for MSU crystal deposition is also lower in the general population.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/934314
Keywords: Gout; Crystal arthritis; Ultrasonography; Hyperuricemia; Asymptomatic gout
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
Identification Number: https://doi.org/10.1002/art.40572
Depositing User: Abhishek, Abhishek
Date Deposited: 01 Jun 2018 08:09
Last Modified: 04 May 2020 19:37
URI: http://eprints.nottingham.ac.uk/id/eprint/52168

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