Gainfully employing descending controls in acute and chronic pain management

White, Kate, Targett, Mike and Harris, John (2018) Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237 . pp. 16-1255. ISSN 1532-2971

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Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive information to the higher centres in the brain. Irrespective of the presence or absence of nociceptive inflow the activity of dorsal horn neurones is modulated by, amongst other things, local interneurones and descending midbrain and brainstem networks which can inhibit or facilitate dorsal horn transmission. These pathways therefore set the threshold for information inflow to the CNS. This review article summarises the anatomy, physiology and pharmacology particularly of these descending inhibitory and facilitatory pathways and explains why the study of descending modulation is essential if we are to develop more efficacious interventions for treating pain and relieving suffering.

Item Type: Article
Keywords: Analgesia; DNIC; Nociception; Pain modulation
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
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Depositing User: Eprints, Support
Date Deposited: 23 May 2018 10:54
Last Modified: 04 May 2020 19:48

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