Garlic and gaseous mediators

Rose, Peter and Moore, Philip Keith and Zhu, Yi-Zhun (2018) Garlic and gaseous mediators. Trends in Pharmacological Sciences . ISSN 1873-3735

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Abstract

Garlic (Allium sativum) and allied plant species are rich sources of sulfur compounds. Major roles for garlic and its sulfur constituents include the regulation of vascular homeostasis and the control of metabolic systems linked to nutrient metabolism. Recent studies have indicated that some of these sulfur compounds, such as diallyl trisulfide (DATS), alter the levels of gaseous signalling molecules including nitric oxide (NO), hydrogen sulfide (H2S), and perhaps carbon monoxide (CO) in mammalian tissues. These gases are important in cellular processes associated with the cardiovascular system, inflammation, and neurological functions. Importantly, these studies build on the known biological effects of garlic and associated sulfur constituents. This review highlights our current understanding of the health benefits attributed to edible plants like garlic.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/928783
Keywords: Hydrogen sulfide; Nitric oxide; Carbon monoxide; Gaseous mediators; Garlic; Polysulfide
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Nutritional Sciences
Identification Number: https://doi.org/10.1016/j.tips.2018.03.009
Depositing User: Eprints, Support
Date Deposited: 22 May 2018 11:46
Last Modified: 04 May 2020 19:33
URI: http://eprints.nottingham.ac.uk/id/eprint/51946

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