New therapeutic targets for osteoarthritis pain

Walsh, David A. and Stocks, Joanne (2017) New therapeutic targets for osteoarthritis pain. Slas Discovery, 22 (8). pp. 931-949. ISSN 2472-5552

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Abstract

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Medications that might reduce pain by slowing or preventing structural disease remain elusive. Our increasing understanding of the complex mechanisms that underlie OA pain offers a wide range of potential new treatment targets. New drugs for OA pain might come from repurposing those developed for other conditions, as well as novel compounds targeting pain mechanisms specific to the joint. Here we discuss the mechanisms of OA pain and its therapeutic implications. We explore evolving treatment modalities, including combination treatment. We review recent research and patents pointing to future OA therapies. We discuss the potential for biomarkers to facilitate drug development and targeting.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/864903
Keywords: osteoarthritis, pain, inflammation, osteoclasts, peripheral sensitization, central sensitizatio
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
Identification Number: https://doi.org/10.1177/2472555217716912
Depositing User: Healy, Jane
Date Deposited: 21 May 2018 14:30
Last Modified: 04 May 2020 18:49
URI: http://eprints.nottingham.ac.uk/id/eprint/51924

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