Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthmaTools Hekking, Pieter-Paul, Loza, Matthew J., Pavlidis, Stelios, De Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Frederic, Auffray, Charles, Wagener, Ariane H., Brinkman, Paul, Lutter, René, Bansal, Aruna T., Sousa, Ana R., Bates, Stewart A., Pandis, Ioannis, Fleming, Louise J., Shaw, Dominick E., Fowler, Stephen J., Guo, Yike, Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter, Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko and Sterk, Peter J. (2017) Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma. European Respiratory Journal, 50 (3). p. 1602298. ISSN 1399-3003 Full text not available from this repository.
Official URL: https://doi.org/10.1183/13993003.02298-2016
AbstractA proportion of severe asthma patients suffers from persistent airflow limitation (PAL), often associated with more symptoms and exacerbations. Little is known about the underlying mechanisms. Here, our aim was to discover unexplored potential mechanisms using Gene Set Variation Analysis (GSVA), a sensitive technique that can detect underlying pathways in heterogeneous samples.
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