Post infectious IBS: defining its clinical features and prognosis using an internet-based survey

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Card, Timothy and Enck, Paul and Barbara, Giovanni and Boeckxstaens, Guy E.E and Santos, Javier and Azpiroz, Fernando and Mearin, Fermin and Aziz, Qasim and Marshall, John and Spiller, Robin C. (2018) Post infectious IBS: defining its clinical features and prognosis using an internet-based survey. United European Gastroenterology Journal . ISSN 2050-6414

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Abstract

Background: Gastrointestinal infection is an important risk factor for developing IBS. Our aim was to characterise postinfectious IBS (PI-IBS) compared to other IBS patients.

Methods: An internet survey of IBS patients using Rome III diagnostic questionnaire, Hospital Anxiety & Depression Scale (HADS) and Patient Health Questionnaire-12 somatic symptom score (PHQ12-SS) documenting the mode of onset.

Results: 7811 participants, 63.2% female of whom 1004 (13.3%) met criteria for PI-IBS. 70% of PI-IBS described sudden onset, 35% onset while travelling, 49.6% vomiting, 49.9 fever and 20.3% bloody diarrhoea. Compared to other IBS, PI-IBS was significantly associated with living in Northern Europe and North America, having a hysterectomy, not having an appendectomy, higher PHQ12-SS score and having more than one toilet in the family home. PI-IBS patients had more frequent stools. At 1 year recovery rate in PI-IBS and non-PI-IBS group was 19.7% and 22.2%, p=0.15. Recovery rates were lower for females (20.7%) versus males (38.8%), those with somatisation ( 23.0%) versus those without (33.2%) and living in North America or Northern Europe (21.1%) versus living elsewhere (33.9%) p=<0.001.

Conclusion: PI-IBS accounts for around 13% of all IBS in this internet sample, with some distinctive features but a similar prognosis to the remainder.

Item Type: Article
Additional Information: Reprinted by permission of SAGE Publications.
Keywords: Infection, Irritable bowel syndrome, Survey, Multinational, Diarrhoea
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number: https://doi.org/10.1177/2050640618779923
Depositing User: Claringburn, Tara
Date Deposited: 11 May 2018 07:45
Last Modified: 05 Jun 2018 10:14
URI: https://eprints.nottingham.ac.uk/id/eprint/51696

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