Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, Karen and Wardlaw, Joanna M. and van Agtmael, Tom and Allan, Stuart M. and Ashford, Mike L.J. and Bath, Philip M. and Brown, Rosalind and Berwick, Jason and Cader, M. Zameel and Carare, Roxana O. and Davis, John B. and Duncombe, Jessica and Farr, Tracy D. and Fowler, Jill H. and Goense, Jozien and Granata, Alessandra and Hall, Catherine N. and Hainsworth, Atticus H. and Harvey, Adam and Hawkes, Cheryl A. and Joutel, Anne and Kalaria, Rajesh N. and Kehoe, Patrick G. and Lawrence, Catherine B. and Lockhart, Andy and Love, Seth and Macleod, Malcolm R. and Macrae, I. Mhairi and Markus, Hugh S. and McCabe, Chris and McColl, Barry W. and Meakin, Paul J. and Miller, Alyson and Nedergaard, Maiken and O'Sullivan, Michael and Quinn, Terry J. and Rajani, Rikesh and Saksida, Lisa M. and Smith, Colin and Smith, Kenneth J. and Touyz, Rhian M. and Trueman, Rebecca C. and Wang, Tao and Williams, Anna and Williams, Steven C.R. and Work, Lorraine M. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132 (8). pp. 851-868. ISSN 0143-5221

Full text not available from this repository.

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/929681
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1042/CS20171620
Depositing User: Eprints, Support
Date Deposited: 08 May 2018 13:04
Last Modified: 04 May 2020 19:34
URI: http://eprints.nottingham.ac.uk/id/eprint/51628

Actions (Archive Staff Only)

Edit View Edit View