Whole brain comparative anatomy using connectivity blueprints

Mars, Rogier B. and Sotiropoulos, Stamatios N. and Passingham, Richard E. and Sallet, Jerome and Verhagen, Lennart and Khrapitchev, Alexandre A. and Sibson, Nicola and Jbabdi, Saad (2018) Whole brain comparative anatomy using connectivity blueprints. eLife, 7 . e35237/1-e35237/15. ISSN 2050-084X

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Abstract

Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/932053
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: https://doi.org/10.7554/eLife.35237
Depositing User: Eprints, Support
Date Deposited: 08 May 2018 10:52
Last Modified: 04 May 2020 19:36
URI: http://eprints.nottingham.ac.uk/id/eprint/51616

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