Nucleoside based self-assembling drugs for localized drug delivery

Skilling, Kathryn J. and Stocks, Michael J. and Kellam, Barrie and Ashford, Marianne and Bradshaw, Tracey and Burroughs, Laurence and Marlow, Maria (2018) Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem . ISSN 1860-7179

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Abstract

We have synthesized a range of gelators based on nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and TEM. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside based gelators for localized drug delivery.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/930416
Additional Information: This is the peer-reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800063. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: drug delivery ; gels ; gemcitabine ; lamivudine ; nucleosides
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1002/cmdc.201800063
Depositing User: Eprints, Support
Date Deposited: 03 May 2018 08:54
Last Modified: 04 May 2020 19:35
URI: http://eprints.nottingham.ac.uk/id/eprint/51547

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