An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation

Saffaran, Sina and Wang, Wenfei and Das, Anup and Schmitt, Walter and Becker-Pelster, Eva-Maria and Hardman, Jonathan G. and Weimann, Gerrit and Bates, Declan G. (2018) An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation. CPT: Pharmacometrics & Systems Pharmacology . ISSN 2163-8306

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Abstract

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) as a complication. Three virtual COPD patients were configured in the simulator based on clinical data. In agreement with previous clinical studies, modeling systemic application of a soluble guanylate cyclase (sGC) modulator results in reduced partial pressure of oxygen (PaO2) and increased partial pressure of carbon dioxide (PaCO2) in arterial blood, if a drug-induced reduction of pulmonary vascular resistance (PVR) equal to that observed experimentally is assumed. In contrast, for administration via dry powder inhalation (DPI), our simulations suggest that the treatment results in no deterioration in oxygenation. For patients under exercise, DPI administration lowers PH while oxygenation is improved with respect to baseline values.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/944862
Keywords: pulmonary hypertension, chronic obstructive pulmonary disease, soluble guanylate cyclase modulators, computer simulation
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: https://doi.org/10.1002/psp4.12308
Depositing User: Eprints, Support
Date Deposited: 02 May 2018 12:11
Last Modified: 04 May 2020 19:44
URI: http://eprints.nottingham.ac.uk/id/eprint/51531

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