Translating childhood brain tumour research into clinical practice: the experience of molecular classification and diagnostics

Ritzmann, Timothy A. and Grundy, Richard G. (2018) Translating childhood brain tumour research into clinical practice: the experience of molecular classification and diagnostics. Paediatrics and Child Health, 28 (4). pp. 177-182. ISSN 1751-7222

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Abstract

Diagnosis and treatment of paediatric brain tumours has shown limited progress over the last half century. However, in the past 10 years the development of molecular techniques for investigating these tumours has expanded exponentially. The use of methylation profiling, gene expression analysis and the identification of gene fusions are forming the basis for improved diagnostic criteria and new treatment approaches. Knowledge and practice in this area is now beginning to expand beyond the research field and into the clinical setting. As the Chief Medical Officer highlighted in July 2017, an understanding of molecular medicine and its implications for both patients and the health economy is important for all clinicians. In this article, we summarise important recent advances in molecular medicine in childhood brain tumour research using the three most common types of paediatric brain tumour; pilocytic astrocytoma, medulloblastoma and ependymoma as illustrative examples.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/930009
Keywords: Brain tumours; DNA methylation; Ependymoma; Fusion genes; Medulloblastoma; Molecular diagnostics; Pilocytic astrocytoma
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: https://doi.org/10.1016/j.paed.2018.01.006
Depositing User: Shreeve, Claire
Date Deposited: 27 Apr 2018 08:35
Last Modified: 04 May 2020 19:34
URI: http://eprints.nottingham.ac.uk/id/eprint/51416

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