Drug delivery across length scales

Delcassian, Derfogail and Patel, Asha K. and Cortinas, Abel B. and Langer, Robert (2018) Drug delivery across length scales. Journal of Drug Targeting, 27 (3). pp. 229-243. ISSN 1029-2330

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Abstract

Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic acids. The use of potent drugs which target specific organs, cells or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets. Here, we review the miniaturisation of drug delivery systems from the macro to nano-scale, focussing on controlled dosing and controlled targeting as two key parameters in drug delivery device design. We describe how the miniaturisation of these devices enables the move from repeated, systemic dosing, to on-demand, targeted delivery of therapeutic drugs and highlight areas of focus for the future.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/912380
Keywords: Drug delivery, length scale, targeting, macro, micro, nano
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1080/1061186X.2018.1438440
Depositing User: Eprints, Support
Date Deposited: 25 Apr 2018 09:03
Last Modified: 04 May 2020 19:32
URI: http://eprints.nottingham.ac.uk/id/eprint/51368

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