Anaerobic radical enzymes for biotechnology

Jäger, Christof M. and Croft, Anna K. (2018) Anaerobic radical enzymes for biotechnology. ChemBioEng Reviews, 5 (3). ISSN 2196-9744

Full text not available from this repository.

Abstract

Enzymes that proceed through radical intermediates have a rich chemistry that includes functionalisation of otherwise unreactive carbon atoms, carbon-skeleton rearrangements, aromatic reductions, and unusual eliminations. Especially under anaerobic conditions, organisms have developed a wide range of approaches for managing these transformations that can be exploited to generate new biological routes towards both bulk and specialty chemicals. These routes are often either much more direct or allow access to molecules that are inaccessible through standard (bio)chemical approaches. This review gives an overview of some of the key enzymes in this area: benzoyl-CoA reductases (that effect the enzymatic Birch reduction), ketyl radical dehydratases, coenzyme B12-dependant enzymes, glycyl radical enzymes, and radical SAM (AdoMet radical) enzymes. These enzymes are discussed alongside biotechnological applications, highlighting the wide range of actual and potential uses. With the increased diversity in biotechnological approaches to obtaining these enzymes and information about them, even more of these amazing enzymes can be expected to find application in industrial processes.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/928719
Additional Information: This is the peer reviewed version of the following article: Jäger, C. M. and Croft, A. K. (2018), Anaerobic Radical Enzymes for Biotechnology. CBEN. doi:10.1002/cben.201800003 which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/cben.201800003 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Radicals, Enzymes, Catalysis, Biotechnology, Anaerobic reactions
Schools/Departments: University of Nottingham, UK > Faculty of Engineering > Department of Chemical and Environmental Engineering
Identification Number: https://doi.org/10.1002/cben.201800003
Depositing User: Eprints, Support
Date Deposited: 23 Apr 2018 12:51
Last Modified: 04 May 2020 19:33
URI: http://eprints.nottingham.ac.uk/id/eprint/51326

Actions (Archive Staff Only)

Edit View Edit View