Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor

Limón, David and Jiménez-Newman, Claire and Calpena, Ana C. and González-Campo, Arántzazu and Amabilino, David B. and Pérez-Garcia, Lluïsa (2017) Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53 . pp. 4509-4512. ISSN 1364-548X

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Abstract

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug releasefrom the gel. Drug release and skin permeation experiments show its potential for topical administration.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/851901
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1039/C6CC09392B
Depositing User: Perez Garcia, Lluisa
Date Deposited: 23 Apr 2018 09:36
Last Modified: 04 May 2020 18:38
URI: http://eprints.nottingham.ac.uk/id/eprint/51297

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