Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitorTools Limón, David, Jiménez-Newman, Claire, Calpena, Ana C., González-Campo, Arántzazu, Amabilino, David B. and Pérez-Garcia, Lluïsa (2017) Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53 . pp. 4509-4512. ISSN 1364-548X Full text not available from this repository.AbstractGels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug releasefrom the gel. Drug release and skin permeation experiments show its potential for topical administration.
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