Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study

Mohan, Divya and Forman, Julia R. and Allinder, Matthew and McEniery, Carmel M. and Bolton, Charlotte Emma and Cockcroft, John R. and MacNee, William and Fuld, Jonathan and Marchong, Mellone and Gale, Nichola Sian and Fisk, Marie and Nagarajan, Sridevi and Cheriyan, Joseph and Lomas, David A. and Calverley, Peter M.A. and Miller, Bruce E. and Tal-Singer, Ruth and Wilkinson, Ian B. and Polkey,, Michael I. (2018) Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax . ISSN 1468-3296

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Abstract

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator—fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II–IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
Identification Number: https://doi.org/10.1136/thoraxjnl-2018-211556
Depositing User: Claringburn, Tara
Date Deposited: 18 Apr 2018 10:13
Last Modified: 08 May 2020 09:02
URI: http://eprints.nottingham.ac.uk/id/eprint/51208

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