A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis)

Wanelik, Klara M., Begon, Michael, Birtles, Richard J., Bradley, Janette E., Friberg, Ida M., Jackson, Joseph A., Taylor, Christopher H., Thomason, Anna G., Turner, Andrew K. and Paterson, Steve (2018) A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis). Molecular Ecology, 27 (4). pp. 1044-1052. ISSN 1365-294X

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The animal immune response has hitherto been viewed primarily in the context of resistance only. However, individuals can also employ a tolerance strategy to maintain good health in the face of ongoing infection. To shed light on the genetic and physiological basis of tolerance, we use a natural population of field voles, Microtus agrestis, to search for an association between the expression of the transcription factor Gata3, previously identified as a marker of tolerance in this system, and polymorphism in 84 immune and nonimmune genes. Our results show clear evidence for an association between Gata3 expression and polymorphism in the Fcer1a gene, with the explanatory power of this polymorphism being comparable to that of other nongenetic variables previously identified as important predictors of Gata3 expression. We also uncover the possible mechanism behind this association using an

existing protein–protein interaction network for the mouse model rodent, Mus musculus, which we validate using our own expression network for M. agrestis. Our results suggest that the polymorphism in question may be working at the transcriptional level, leading to changes in the expression of the Th2-related genes, Tyrosine-protein kinase BTK and Tyrosine-protein kinase TXK, and hence potentially altering the strength of the Th2 response, of which Gata3 is a mediator. We believe our work has implications for both treatment and control of infectious disease.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/910849
Keywords: disease ecology, eco-immunology, Fcer1a, Gata3, immune strategy
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1111/mec.14476
Depositing User: Eprints, Support
Date Deposited: 06 Apr 2018 12:30
Last Modified: 04 May 2020 19:31
URI: https://eprints.nottingham.ac.uk/id/eprint/50989

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