Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence

Hahamy, Avital and Sotiropoulos, Stamatios N. and Henderson Slater, David and Malach, Rafael and Johansen-Berg, Heidi and Makin, Tamar R. (2015) Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence. eLife, 4 . e04605/1-e04605/12. ISSN 2050-084X

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Abstract

Previously we showed, using task-evoked fMRI, that compensatory intact hand usage after amputation facilitates remapping of limb representations in the cortical territory of the missing hand (Makin et al., 2013a). Here we show that compensatory arm usage in individuals born without a hand (one-handers) reflects functional connectivity of spontaneous brain activity in the cortical hand region. Compared with two-handed controls, one-handers showed reduced symmetry of hand region inter-hemispheric resting-state functional connectivity and corticospinal white matter microstructure. Nevertheless, those one-handers who more frequently use their residual (handless) arm for typically bimanual daily tasks also showed more symmetrical functional connectivity of the hand region, demonstrating that adaptive behaviour drives long-range brain organisation. We therefore suggest that compensatory arm usage maintains symmetrical sensorimotor functional connectivity in one-handers. Since variability in spontaneous functional connectivity in our study reflects ecological behaviour, we propose that inter-hemispheric symmetry, typically observed in resting sensorimotor networks, depends on coordinated motor behaviour in daily life.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.7554/eLife.04605.001
Depositing User: Eprints, Support
Date Deposited: 05 Apr 2018 09:45
Last Modified: 05 Apr 2018 13:18
URI: http://eprints.nottingham.ac.uk/id/eprint/50951

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