The Human Connectome Project's neuroimaging approach

Glasser, Matthew F. and Smith, Stephen M. and Marcus, Daniel S. and Andersson, Jesper L.R. and Auerbach, Edward J. and Behrens, Timothy E.J. and Coalson, Timothy S. and Harms, Michael P. and Jenkinson, Mark and Moeller, Steen and Robinson, Emma C. and Sotiropoulos, Stamatios N. and Xu, Junqian and Yacoub, Essa and Ugurbil, Kamil and Van Essen, David C. (2016) The Human Connectome Project's neuroimaging approach. Nature Neuroscience, 19 (9). pp. 1175-1187. ISSN 1546-1726

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Abstract

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.

Item Type: Article
Keywords: Language; Neural circuits; Sensory processing
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.1038/nn.4361
Depositing User: Eprints, Support
Date Deposited: 05 Apr 2018 09:28
Last Modified: 05 Apr 2018 13:37
URI: http://eprints.nottingham.ac.uk/id/eprint/50950

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