Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study

Matthews, Yim-Yee and Dean, Fiona and Lim, Ming J. and Mclachlan, Karen and Rigby, Alan S. and Solanki, Guirish A. and White, Catherine P. and Whitehouse, William P. and Kennedy, Colin R. (2017) Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. Archives of Disease in Childhood, 102 (8). pp. 715-721. ISSN 1468-2044

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Abstract

AIM:

To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years.

METHODS:

A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using classical diagnostic criteria and categorised according to 2013 revised diagnostic criteria. We derived national age, sex and weight-specific annual incidence rates and assessed effects of sex and weight categories.

RESULTS:

We identified 185 PTCS cases of which 166 also fulfilled revised diagnostic criteria. The national annual incidence (95% CI) of PTCS in children aged 1-16 years was 0.71 (0.57 to 0.87) per 100 000 population increasing with age and weight to 4.18 and 10.7 per 100 000 in obese boys and girls aged 12-15 years, respectively. Incidence rates under 7 years were similar in both sexes. From 7 years onwards, the incidence in girls was double that in boys, but only in overweight (including obese) children. In children aged 12-15 years, an estimated 82% of the incidence of PTCS was attributable to obesity. Two subgroups of PTCS were apparent: 168 (91%) cases aged from 7 years frequently presented on medication and with headache and were predominantly female and obese. The remaining 17 (9%) cases under 7 years often lacked these risk factors and commonly presented with paralytic squint.

CONCLUSIONS:

This uniquely large population-based study of childhood PTCS will inform the design of future intervention studies. It suggests that weight reduction is central to the prevention of PTCS.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

KEYWORDS:

BPSU; Epidemiology; Obesity; idiopathic intracranial hypertension; pseudotumor cerebri

PMID: 28356250 DOI: 10.1136/archdischild-2016-312238

[Indexed for MEDLINE]

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1136/archdischild-2016-312238
Depositing User: Shreeve, Claire
Date Deposited: 05 Apr 2018 10:42
Last Modified: 05 Apr 2018 13:18
URI: http://eprints.nottingham.ac.uk/id/eprint/50837

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