Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)

Barratt, Shaney L. and Blythe, Thomas and Ourradi, Khadija and Jarrett, Caroline and Welsh, Gavin I. and Bates, David O. and Millar, Ann B. (2018) Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF). Respiratory Research, 19 . p. 9. ISSN 1465-9921

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Abstract

Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Aa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Aa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Aa isoforms as drivers of fibrogenesis.

Item Type: Article
Keywords: Interstitial lung disease, Vascular endothelial growth factor, Hypoxia, Idiopathic pulmonary fibrosis
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: https://doi.org/10.1186/s12931-017-0711-x
Depositing User: Bates, David
Date Deposited: 05 Mar 2018 13:11
Last Modified: 06 Mar 2018 12:18
URI: http://eprints.nottingham.ac.uk/id/eprint/50178

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