Albaugh, Matthew, Ivanova, Masha, Chaarani, Bader, Orr, Catherine, Allgaier, Nicholas, Althoff, Robert, D'Alberto, Nicholas, Hudson, Kelse, Mackey, Scott, Spechler, Philip, Banaschewski, Tobias, Bokde, Arun, Bromberg, Uli, Cattrell, Anna, J.Conrod, Patricia and Gowland, Penny
(2018)
Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood.
Cerebral Cortex, 29
(5).
pp. 1866-1874.
ISSN 1460-2199
Abstract
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1,104 participants (M = 14.52 yrs, SD = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -.274, p < .001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.
| Item Type: |
Article
|
| Additional Information: |
37 authors in total.
This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at: https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy066/4975485 |
| Keywords: |
attention-deficit/hyperactivity disorder, neuroimaging, ventromedial prefrontal cortex |
| Schools/Departments: |
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy |
| Identification Number: |
10.1093/cercor/bhy066 |
| Depositing User: |
Eprints, Support
|
| Date Deposited: |
27 Feb 2018 09:59 |
| Last Modified: |
16 May 2019 14:07 |
| URI: |
https://eprints.nottingham.ac.uk/id/eprint/50041 |
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