Pulmonary basaloid squamous cell carcinoma in a dog

Morey-Matamalas, Antonia and de Stefani, Alberta and Corbetta, Davide and Grau-Roma, Llorenc and de Brot, Simone (2018) Pulmonary basaloid squamous cell carcinoma in a dog. Journal of Comparative Pathology, 159 . pp. 11-15. ISSN 1532-3129

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A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the cerebellum. Microscopically, the tumour consisted of an infiltrative, densely cellular, basaloid epithelial neoplastic growth with extensive areas of abrupt keratinization. Immunohistochemically, neoplastic cells expressed p63 and partially expressed cytokeratins 5/6. Based on these findings, the tumour was diagnosed as a primary pulmonary basaloid squamous cell carcinoma (BSSC) with metastasis to regional lymph nodes, kidney and brain. As far as the authors are aware, this is the first description of BSCC in an animal species.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1016/j.jcpa.2017.12.007
Depositing User: de Brot, Dr Simone
Date Deposited: 26 Feb 2018 10:29
Last Modified: 26 Feb 2018 10:29
URI: http://eprints.nottingham.ac.uk/id/eprint/49991

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