Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception

Muir, Ronan Davidson and Liu, Ge and Khan, Raheela and Shmygol, Anatoly and Quenby, Siobhan and Gibson, Robert Alan and Muhlhausler, Beverly and Elmes, Matthew (2018) Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception. Scientific Reports, 8 . 3389/1-3389/11. ISSN 2045-2322

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Abstract

Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty acids (FA) for prostaglandin synthesis and whether any changes could be reversed by improved nutrition post-conception. Wistar rats were fed control (CON) or High-Fat, High-cholesterol (HFHC) diets 6 weeks before mating. At conception half the dams switched diets providing 4 dietary groups: (1) CON, (2) HFHC, (3) CON-HFHC or (4) HFHC-CON. During parturition rats were euthanized and FA composition of plasma, liver and uterus determined. Visceral fat was doubled in rats exposed to the HFHC diet prior to and/or during pregnancy compared to CON. HFHC diet increased MUFAs but decreased omega-3 and omega-6 PUFAs in plasma and liver. Uterine omega-3 FA concentrations were halved in HFHC versus CON rats, but all other FAs were similar. Switching from HFHC to CON diet at conception restored all FA profles to those seen in CON rats. The increased MUFA and decreased PUFA concentrations in obese HFHC dams may contribute to aberrant prostaglandin synthesis and dysfunctional myometrial activity and it may be possible to reverse these changes, and potentially improve labour outcomes, by improving nutrition at conception.

Item Type: Article
Keywords: Maternal obesity; Polyunsaturated fatty acids; Change of diet at conception; Uterus; Improved nutrition
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine
University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Nutritional Sciences
Identification Number: https://doi.org/10.1038/s41598-018-21809-9
Depositing User: Elmes, Matthew
Date Deposited: 21 Feb 2018 15:06
Last Modified: 21 Feb 2018 18:26
URI: http://eprints.nottingham.ac.uk/id/eprint/49910

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