Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

Geary, Gemma C., Nortcliffe, Andrew, Pearce, Christopher A., Hamza, Daniel, Jones, Geraint and Moody, Christopher J. (2017) Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery. Bioorganic & Medicinal Chemistry . ISSN 0968-0896

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Abstract

A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/898934
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1016/j.bmc.2017.12.012
Depositing User: Smith, Ruth
Date Deposited: 16 Feb 2018 14:01
Last Modified: 04 May 2020 19:21
URI: https://eprints.nottingham.ac.uk/id/eprint/49828

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