Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge

Feldwisch-Drentrup, Hinnerk and Barrett, Adam B. and Smith, Michael T. and van Rossum, Mark C.W. (2012) Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210 (1). pp. 15-21. ISSN 1872-678X

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Abstract

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/711403
Keywords: Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.1016/j.jneumeth.2011.11.004
Depositing User: Van Rossum, Mark CW
Date Deposited: 07 Feb 2018 14:51
Last Modified: 04 May 2020 16:34
URI: http://eprints.nottingham.ac.uk/id/eprint/49641

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