Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output

Schiemann, Julia and Puggioni, Paolo and Dacre, Joshua and Pelko, Miha and Domanski, Aleksander and van Rossum, Mark C.W. and Duguid, Ian (2015) Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output. Cell Reports, 11 (8). pp. 1319-1330. ISSN 2211-1247

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Abstract

Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. Here, we performed in vivo patch-clamp recordings from layer 5B (L5B) pyramidal neurons in awake mice during quiet wakefulness and self-paced, voluntary movement. We show that L5B output neurons display bidirectional (i.e., enhanced or suppressed) firing rate changes during movement, mediated via two opposing subthreshold mechanisms: (1) a global decrease in membrane potential variability that reduced L5B firing rates (L5Bsuppressed neurons), and (2) a coincident noradrenaline-mediated increase in excitatory drive to a subpopulation of L5B neurons (L5Benhanced neurons) that elevated firing rates. Blocking noradrenergic receptors in forelimb M1 abolished the bidirectional modulation of M1 output during movement and selectively impaired contralateral forelimb motor coordination. Together, our results provide a mechanism for how noradrenergic neuromodulation and network-driven input changes bidirectionally modulate M1 output during motor behavior.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.1016/j.celrep.2015.04.042
Depositing User: Van Rossum, Mark
Date Deposited: 08 Feb 2018 14:16
Last Modified: 08 Feb 2018 14:19
URI: http://eprints.nottingham.ac.uk/id/eprint/49633

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