Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

Costa, Rui Ponte and Froemke, Robert C. and Sjöström, P. Jesper and van Rossum, Mark C.W. (2015) Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4 . e09457. ISSN 2050-084X

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Abstract

Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.7554/eLife.09457
Depositing User: Van Rossum, Mark
Date Deposited: 07 Feb 2018 14:32
Last Modified: 08 Feb 2018 15:23
URI: http://eprints.nottingham.ac.uk/id/eprint/49628

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