Functional consequences of pre- and postsynaptic expression of synaptic plasticity

Costa, Rui Ponte and Mizusaki, Beatriz E.P. and Sjöström, P. Jesper and van Rossum, Mark C.W. (2017) Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372 (1715). pp. 1-10. ISSN 1471-2970

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Abstract

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

Item Type: Article
Keywords: synaptic plasticity, Hebbian plasticity, spike-timing-dependent plasticity, homoeostatic plasticity, long-term potentiation, synaptic release
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: 10.1098/rstb.2016.0153
Depositing User: Van Rossum, Mark
Date Deposited: 07 Feb 2018 15:44
Last Modified: 08 Feb 2018 10:59
URI: http://eprints.nottingham.ac.uk/id/eprint/49625

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