Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery

Louzao, Iria and Koch, Britta and Taresco, Vincenzo and Ruiz Cantu, Laura and Irvine, Derek J. and Roberts, Clive J. and Tuck, Christopher J. and Alexander, Cameron and Hague, Richard J.M. and Wildman, Ricky D. and Alexander, Morgan R. (2018) Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery. ACS Applied Materials & Interfaces, 10 (8). pp. 6841-6848. ISSN 1944-8244

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Abstract

A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of objects architectures. A full drug release study, degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties.

Item Type: Article
Keywords: 3D printing, Drug Delivery, Polymer materials, Biomedical devices, Sustained drug release
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1021/acsami.7b15677
Depositing User: Eprints, Support
Date Deposited: 15 Jan 2018 15:43
Last Modified: 02 Jul 2018 09:17
URI: http://eprints.nottingham.ac.uk/id/eprint/49114

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