A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis

Gao, Yi-Qun and Chen, Jiu-Geng and Chen, Zi-Ru and An, Dong and Lv, Qiao-Yan and Han, Mei-Ling and Wang, Ya-Ling and Salt, David E. and Chao, Dai-Yin (2017) A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis. PLoS Biology, 15 (12). e2002978/1-e2002978/27. ISSN 1545-7885

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Abstract

Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/901814
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences
Identification Number: https://doi.org/10.1371/journal.pbio.2002978
Depositing User: Eprints, Support
Date Deposited: 11 Jan 2018 09:43
Last Modified: 04 May 2020 19:24
URI: http://eprints.nottingham.ac.uk/id/eprint/49028

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