Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging

Zamberlan, F. and Turyanska, L. and Patanè, A. and Liu, Z. and Williams, H.E.L. and Fay, M.W. and Clarke, P.A. and Imamura, Y. and Jin, T. and Bradshaw, T.D. and Thomas, N.R. and Grabowska, A.M. (2018) Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6 . pp. 550-555. ISSN 2050-7518

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Abstract

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
University of Nottingham, UK > Faculty of Science > School of Chemistry
University of Nottingham, UK > Faculty of Science > School of Pharmacy
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: 10.1039/c7tb02912h
Depositing User: Eprints, Support
Date Deposited: 08 Jan 2018 11:44
Last Modified: 31 Jan 2018 05:23
URI: http://eprints.nottingham.ac.uk/id/eprint/48975

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