Digalactoside expression in the lipopolysaccharide of haemophilus influenzae and its role in intravascular survival

Griffin, R. and Bayliss, Christopher D. and Herbert, Mark A. and Cox, Andrew D. and Makepeace, Katherine and Richards, J.C. and Hood, Derek W. and Moxon, E. Richard (2005) Digalactoside expression in the lipopolysaccharide of haemophilus influenzae and its role in intravascular survival. Infection and Immunity, 73 (10). pp. 7022-7026. ISSN 1098-5522

[img] PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (172kB)

Abstract

Digalactoside (gal-1-4 gal) structures of the lipopolysaccharide (LPS) of Haemophilus influenzae are implicated in virulence. A confounding factor is that tetranucleotide repeats within the lic2A, lgtC, and lex2 genes mediate phase-variable expression of the digalactosides. By deleting these repeats, we constructed recombinant strains of RM153 constitutively expressing either one or two LPS digalactosides. Expression of two digalactosides, rather than one, was associated with increased virulence of H. influenzae in vivo.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Bacteriology
Identification Number: https://doi.org/10.1128/IAI.73.10.7022-7026.2005
Depositing User: Griffin, Ruth
Date Deposited: 14 Dec 2017 15:06
Last Modified: 14 Dec 2017 15:29
URI: http://eprints.nottingham.ac.uk/id/eprint/48702

Actions (Archive Staff Only)

Edit View Edit View