Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages

Rosas-Magallanes, Vania and Stadthagen-Gomez, Gustavo and Rauzier, Jean and Barreiro, Luis B. and Tailleux, Ludovic and Boudou, Frédéric and Griffin, Ruth and Nigou, Jérome and Jackson, Mary and Gicquel, Brigittte and Neyrolles, Olivier (2007) Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infection and Immunity, 75 (1). 504 -507. ISSN 1098-5522

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Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Bacteriology
Identification Number: https://doi.org/10.1128/IAI.00058-06.
Depositing User: Griffin, Ruth
Date Deposited: 13 Dec 2017 14:25
Last Modified: 14 Dec 2017 11:53
URI: http://eprints.nottingham.ac.uk/id/eprint/48696

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