Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation

Celiz, Adam D. and Smith, James G.W. and Patel, Asha K. and Hook, Andrew L. and Rajamohan, Divya and George, Vinoj T. and Flatt, Luke and Patel, Minal J. and Epa, Vidana C. and Singh, Taranjit and Langer, Robert and Anderson, Daniel G. and Allen, Nicholas D. and Hay, David C. and Winkler, David A. and Barrett, David A. and Davies, Martyn C. and Young, Lorraine E. and Denning, Chris and Alexander, Morgan R. (2015) Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27 (27). pp. 4006-4012. ISSN 0935-9648

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Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

Item Type: Article
Keywords: high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1002/adma.201501351
Depositing User: Eprints, Support
Date Deposited: 07 Dec 2017 13:26
Last Modified: 07 Dec 2017 18:32
URI: http://eprints.nottingham.ac.uk/id/eprint/48601

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