Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiationTools Celiz, Adam D. and Smith, James G.W. and Patel, Asha K. and Hook, Andrew L. and Rajamohan, Divya and George, Vinoj T. and Flatt, Luke and Patel, Minal J. and Epa, Vidana C. and Singh, Taranjit and Langer, Robert and Anderson, Daniel G. and Allen, Nicholas D. and Hay, David C. and Winkler, David A. and Barrett, David A. and Davies, Martyn C. and Young, Lorraine E. and Denning, Chris and Alexander, Morgan R. (2015) Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27 (27). pp. 4006-4012. ISSN 0935-9648
AbstractA scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.
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