Water contact angle is not a good predictor of biological responses to materials

Alexander, Morgan R. and Williams, Paul (2017) Water contact angle is not a good predictor of biological responses to materials. Biointerphases, 12 (2). 02C201. ISSN 1934-8630

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Abstract

Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1116/1.4989843
Depositing User: Eprints, Support
Date Deposited: 06 Dec 2017 15:39
Last Modified: 07 Dec 2017 05:19
URI: http://eprints.nottingham.ac.uk/id/eprint/48589

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